You may be OK It looks nice sitting there and there is little extra forward and back room on the cantilever frame, too. It will be wider than the HS engine, but that isn't a real issue. The HS engine in the Panther frame got very tight at the top so that I had to trim a bit off of the choke lever to make it fit. The lay back tilt of the head on the Greyhound fits in there better than I thought it would. I think you will be OK on the tranny. For sure you will need an extra wide pedal crank. I bought the one piece kind and had to custom fit a sprocket from a kiddy bike, the smallest I could find. The crank I got had a hexagonal keyed center hole, so the little sprocket had to be filed out so it would fit. Not a big deal. I also had to bend the pedal arms to get enough clearance to the side for the pedals to clear the transmission cover so you may need to do that as well. Or you could use pedal extenders to get the pedals out to the side more. You'll know when you get to that point. I'm more hopeful than I was before, but it is still dicey. I sure hope it works out! I'm cheerleadin' for ya!
SB