TBH this thread poses an impossibility, "2 stroke vs 4 stroke" seems a straightforward enough question that's been asked so many times... but it really isn't even a little bit as simple as that as there's so many different types, sizes & qualities to choose from, our differing applications & personal preferences only compounds the confusion. Add in the aforementioned electrics and even hybrid combinations of any/all the above and "which is best" over any other particular type starts to become a question only of what you would choose to play with - rather then the other way around.
Even aside from engine type there's the uses, the personal preferences that may make something "better" for you, but not another - there's nearly an infinite diversity in applications as well from the casual hobbyist, daily rider & commuter, racer, fabricator, vendor & more, even any combinations of the above.
Is maximum horsepower best? What about maximum torque? Gears or no? What if you're not interested in power sports & would rather just ride? What of a bit of both worlds? What of cost effectiveness, is money an issue? If it is, what's best - to buy a quality motor from the get go, or a cheap one & build one up yourself with aftermarket parts? What about buying a quality motor and modifying it to suit? Which brings us back around to personal preference & application again, you gonna build it for speed or reliability, even try for both? What of those parts you need, does the motor type lend itself to such modification in availability of parts & price? Then again, what if you don't like to tinker at all, not interested in building & just wanna ride?
Folks using these things run the full gamut from those seeking just a bit of pedal assistance for those pesky hills to those building motorcycles with vestigial pedals at most, if any at all. Even if you've managed to pick something that seems best for you - even that's only an educated guess based on what you think you'd prefer as it's very unlikely you've tried them all. There's more then a couple few folks that have sworn by something, resolutely claiming it was the numero uno bestist ever... to later try something new and find there's more then they thought to the question, that there isn't any one "best", not even for you.
Personally? My collection includes electrics, two strokes, four strokes, single speeds, internal gearboxes, jackshafts, chain drives & friction in comfy cruisers & racers both...
Which do I like best? *shrug* No idea as depends on the day, my mood & what I feel like playing with at the moment. As a tinker I just like to build stuff so that doesn't help the question, as a daily commuter, weekend cruiser, as one who does occasionally try to race a local 'ped or two... well, it's about which tool for the job sure - but what's the job lol?