That question is often asked. In theory should work as well if the up right angle of the engine is maintained, mainly in regards to the carburator. The structure of most bikes has a sloping rear section so it would require some modification in this regards. Also the engagement/disengagement would have to be adressed behind the rider, maybe a scissor clutch could be used, for inital starting, and free pedaling. I am running the 2.125 tire on the front, it took some "washering" of the engine to keep it centered, but I find the larger tire to smooth the ride. I ride about 400' of gravel drive to the road and the difference between a tire of this size and a 1.95 is noticable. As long as the engine unit is mounted to the traveling fork it should present no problems. The front brakes would probably have to go unless relocated to the rear of the fork, and the fork bridge common on most suspension unit would have to be removed. A solidly mounted engine will serve the same porpose.