My first build was a road bike, a very nice fuji, weighed about a pound, ha.
It had extremely skinny tires.
I dont know if it was where i rode the bike, how i rode it, or some other factor, but after i broke in the motor on it, maybe 15 miles or so later, the back wheel developed a drastic wobble, to where it was hitting the frame nearly.
i think that my experience wasnt atypical tho.
I'd say get the fattest tires that the forks allow.