I think so, especially if you're pedaling with an electric hub.
Don't expect to go 35mph.
Use a shift kit with the engine and gear the 8-speed cassette super low.
You'll have to convert to 78mm clutch, in order to use either the pocket bike 5:1 transmission, or the pocket bike CVT transmission.
Using this clutch adaptor:
http://www.staton-inc.com/store/index.php?p=product&id=875
Try to get 1st gear 46:1 or lower. Highway gear will then be 15:1.
Since you only have a 1-mile highway, you can gear it even stiffer.
Choose the correct chainring to help pedal.
This will take some engineering to gear this engine, or any engine, for that matter.
You could use rear friction drive, but you wouldn't have the gearing.
This might be the perfect engine for your needs. It's 22cc, quality 1.3hp Tanaka engine. The price is awesome too:
http://www.ebay.com/itm/TANAKA-Util...ash=item440023f0b6:g:G7YAAOSw9k5XPnI8&vxp=mtr
FWIW, my bike and I weigh almost 300lbs. With 47cc and gearing, it works very well for me, hills and flats.
However, if I were me, I'd choose a 35cc-up engine which uses the larger 76mm clutch. Then, no expensive adaptor and additional clutch parts.
You'll need the 76mm clutch to bolt on the pocket bikes' 5:1 transmission or 7:1 CVT trans. That's the only way to utilize low gearing and high gearing.