for the amount of effort needed to get a 2-stroke making and using boost, would it not be better to start with a small 4-stroke like a Robin or a Huasheng, maybe even a proper 50cc honda pitbike motor if you can find one.
I would assume an engine like that would cope better with such a set up (maybe I'm wrong) and with the costs involved in putting it together I would rather do with a motor that wouldn't explode.
that said, lets say you either had a custom casting cylinder with a magic port map that lets you pressurise the intake, or an external valve set on your engine: what you will have gained is less that what you would gain from having the same amount of effort and custom work into making a 2-stroke engine just be better. if I have to make a custom jug with a custom port map, why not just make that jug out of stupendously solid alloy with massive intake and exhaust ports instead?
if I could do that i could easily make a custom head to go with it, dual plugs and massive compression.
**** at that point what would be stopping me from custom casting a bottom end as well?
if someone does decide to pull a series of stunts like that and make a china-girl copy of astounding build quality it would likely have comprable perfomance N/A to those KTM50 clones you see.
at that point giving it a turbo starts making some sense. as a bolt on to a stock kit engine? you have a recipe for woe.
if you did manage to do it though... AWESOME!