with its large oxygen content the thermal expansion of the piston and cylinder with even 15%(methanol 60%, castor oil 25%) mix in your stock setup would seize everything up in no time, but you could run it if you run a really rich carburetor setup, teflon fuel lines(nitro is very corrosive), beefy forged/lightweight components, re designed compression ratio(lower for nitro at around 7.5-8:1), a nitro port layout, and degummed castor oil, but why to such a peasant Chinese motor??? nitro is uber pricey as well, it is not worth it unless you re engineer this engine ground up starting off with a 4340 crankshaft...