When you mention blueprinting I already feel out of my league, but I built/modified my own drop loop frame, so I figured I'd offer advice. If you have the engine, I would lay it on its side on some cardboard and sketch out a line that your frame will follow. However, I would also recommend figuring out your drive set up and pedal clearance.
Will you be running a jackshaft? If so, most people locate it in front of the seat post tube, so you may need to locate your engine more forward towards the front wheel than you would think. Also, if you are running bike pedals, you will need to ensure that the pedals will clear the engine, transmission components, and exhaust.
When I was building my frame, I made a life-size drawing of the frame, wheels, and bottom bracket location. It was very helpful in planning.
But you mention blueprinting, so maybe you are doing a CAD drawing? In which case you would just need engine dimensions.
Hope that helped a little,
Gilbert