Fab a jack shaft & add a wide sprocket hub adapter is the quick answer. That is if your frame is large enough to mount a jack shaft as you described it, and if your wheel hub will accept a hub adapter for 3 hole sprockets. Really need photos of the bike and closeups of the rear wheel hub to answer your question. Also what diameter is the rear hub? Is the 80cc engine a Chinese 2 stroke kit motor? Otherwise we're just guessing what you're dealing with.
Rule of thumb 2.5" tires about as wide as you can go without it getting somewhat "complex" which means different things to different builders. The rag joint won't clear wide tires, even with the widest hub clamp sprocket adapter that Curtis mentioned won't clear a 3.5" tire without additional spacing.
Clearing the tire with chain is only one aspect of making this work with a wide tire as the new chain line has to be perfectly straight with the motors output sprocket and also clear the seat stay tube and chain stay. The chain cuts like a saw on both rubber and metal components while even a slightly crooked chain line will cause the chain to jump sprocket or break.
Rick C.