Pilots are aware of 'air density altitude', I think it's called...
...they go to full rich for take-offs, and know it's better to take off with full loads first thing in the morning than waiting 'til later in the day.
IMO, with the little buzzy engines, it's best to tune a bit fatter than optimum hp performance so there is less noticeable difference with temp/humidity/air density changes.
YMMV lol
rc