It depends entirely on how well your bike's built - a good way to look at it is, have you ridden 100 miles before w/o a problem - even if spread out over a coupla days? If so, yer golden as the engine itself has no sense of time, 100 miles in five days or 100 miles in one trip is all the same to it.
If however yer still in the dial-in & tinkering phase, then ya might wanna get that sorted before any "epic" journeys
It's a still good idea to carry some basic tools & spare masterlink & tube, even some of yer fave 2 stroke oil on the longer trips - Murphy loves bikes heh