I answered that question in post #6. Others might have opinons but what I posted can't really be argued with. All single cylinder 2 stroke engines will produce vibrations.
I feel you are overthinking this issue. Don't make your first build any harder than it needs to be. Install the engine as it was designed to be installed, learn some things about it and building a reliable and successful motorized bike. Then later, if you want to experiment and try new things you'll have some experience that will help.
Age and Treachery Will Always Triumph
Over Youth and Skill & "Charlie Don't Ride"