I just fiddle with my 2-stroke here and there to get as much efficiency as she'll muster. I've had her ported, adjusted the needle position, good brand of plug and the right plug gap, performance air filter, aligned the drive chain and trued & aligned the rear wheel to the very best of my ability, lubed darn near everything, etc. All the little things add up.
The other part of the equation is for the rider to do what he/she can. I give her a little time to warm up (not a lot, just a minute or less depending on outdoor temperature). And I'm often conservative with throttle use, when I'm commuting.
I have to confess: when I'm riding for fun, my throttle use is less-than-conservative.