Although this is a boating route there are roads running near or along side that would make for a neat trip. America's Great Loop Cruisers' Association My boat is in SC for the winter and starting up the trip again in the spring.
I had a friend in the 70's that rode (no motor) from Minn. to Wash. to S. Calif. to Texas and home for a nice trip one year.
He found a lot of nice people that put him up and slept in a lot of small town cemetery's. When asked why, he said it was quiet and no one ever bothered him.
Hank