Seriously, you have to put the wheel on the bike or a stand and make an "indicator" to mark alignment and run out, then slowly, carefully tighten it.

Also, check to make sure the hole is drilled on center and if it's not "adjust it".

Having said that, I'll add that on a one bike I never could get it straight (run out 'front to rear') and the only adverse efect it had was a little more noise than normal.

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If it ain't broke, and you mess with it long enough, it will be.