Yes, they can last quite awhile if taken care of properly.

I'd mix the fuel at 24:1 after break in unless you want to do a lot of plug changing and de-carboning.

Common wear items include rings (cheap, easy) chain/sprocket, also cheap and easy and maybe after 5-6000 miles a wrist pin bushing or bearing, depending on your engine. No biggie.

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If it ain't broke, and you mess with it long enough, it will be.